What to do if you think you have the symptoms of anaphylaxis (severe allergic reaction)

Anaphylaxis is a severe allergic reaction which can be potentially life-threatening. It should always be treated as a medical emergency, requiring immediate treatment.1

If your doctor or specialist has diagnosed you or your child with the risk of anaphylaxis (severe allergic reaction),

and you believe symptoms have started, EpiPen® Auto-Injector should be used immediately and call triple zero (000) for an ambulance.

If you or your child have not been diagnosed with the risk of anaphylaxis (severe allergic reaction),

and you believe symptoms have started, call triple zero (000) immediately for an ambulance.

If you're not sure of the signs and symptoms, review the list here.

The following procedure is based on ASCIA Recommendations2


Lay person flat. Do NOT allow them to stand or walk. If unconscious, place in recovery position. If breathing is difficult allow them to sit.


Give EpiPen® Auto-Injector (it can be used through clothing or directly on to the skin).


Remember: Blue to
the sky

Grasp with orange tip pointing downward.
Remove blue safety cap by pulling straight up – do not bend or twist.


Remember: Orange to the thigh.

Place the orange tip against the middle of the outer thigh at a right angle (90-degree angle).
Push the auto-injector firmly into the thigh until a click is heard or felt. Hold firmly in place for 3 seconds and then remove.


Phone for an ambulance - call triple zero (000).


Phone family/emergency contact.


If the signs and symptoms of anaphylaxis don’t improve, or get worse, you can use a second EpiPen® or EpiPen® Jr Auto-Injector, 5-15 minutes after the first dose.
Do not inject more than two sequential doses of EpiPen® Auto-Injector unless under medical supervision.2-4


Transfer the person to hospital for at least 4 hours of observation.

Commence CPR at any time if person is unresponsive and not breathing normally.

Note: ALWAYS give EpiPen® Auto-Injector FIRST, and then asthma reliever puffer if someone with known asthma and allergy to food, insects or medication has SUDDEN BREATHING DIFFICULTY (including wheeze, persistent cough or hoarse voice) even if there are no skin symptoms.

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Warning signs

Sometimes, before an anaphylactic reaction occurs, a person experiences milder symptoms. These may include tingling of the skin or abdominal pain and vomiting. These early symptoms can be a useful warning that exposure to a trigger has occurred, and that treatment may be needed.5
Speak to your doctor about the signs and symptoms of anaphylaxis (severe allergic reaction) and learn the warning signs for you or your child.

If you’re unsure if anaphylaxis is occurring it’s better to use EpiPen® Auto-Injector.6,7

Anaphylaxis = Severe allergic reaction. ASCIA = Australasian Society of Clinical Immunology and Allergy.

Login to MyEpiPen®

Join more than 35,000 EpiPen® Auto-Injector users and reap the benefits1

MyEpiPen® is an online resource dedicated to helping you and your family be better prepared to manage anaphylaxis (severe allergic reaction). If you're not yet a member of MyEpiPen®, make sure you join today to receive:

  • An EpiPen®  Trainer – a training device to help you practise using EpiPen® Auto-Injector
  • How to use EpiPen® Auto-Injector fridge magnet - to serve as a useful reminder
  • Expiry reminders - to help ensure you always have an in-date EpiPen® Auto-Injector at hand
  • Regular updates on the latest anaphylaxis news

Register here

Welcome to MyEpiPen®

Patients and Carers

Our new website is designed to support Australians who have been diagnosed with
severe allergies and are at risk of anaphylaxis.


Schools and Pharmacists

We’re busy working on your new programs, and look forward to welcoming you to the
new site soon. In the meantime, please click below to access the EpiClub® site as usual.

July 2021. EPI-2021-0194.

When collecting your EpiPen® or EpiPen® Jr Auto-Injector prescription, your pharmacist may try to switch it, or talk to you about switching to Anapen®.1

EpiPen® Auto-Injectors and Anapen® are not the same:2-4

EpiPen® takes just 2 steps to use.2,3

Anapen® takes more steps.4

EpiPen® has a Never-See-Needle.™2,3

Anapen®’s needle is exposed after use.4

  • Switching means retraining: You, your family, friends and caregivers must retrain to use a different device correctly if you have an anaphylactic attack2-4
  • Switching means a different ASCIA Action Plan: You will also need to get a new ASCIA Action Plan, specific to Anapen®5

Remember, you don’t have to change. It’s your choice6
Be specific and tell your GP and pharmacist that you want your EpiPen® Auto-Injector prescription.


  1. NPS Medicinewise. Brand equivalence — ‘a’ flagging explained. Available at: https://www.nps.org.au/radar/articles/brand-equivalence-a-flagging-explained. Accessed December 2021.
  2. EpiPen® Adrenaline (epinephrine) 300 μg/0.3 mL Auto-Injector. Consumer Medicine information. July 2021.
  3. EpiPen® Jr. Adrenaline (epinephrine) 150 μg/0.3 mL Auto-Injector. Consumer Medicine information. July 2021.
  4. Anapen® Consumer Medicine information. March 2021.
  5. ASCIA Action Plans for Anaphylaxis (RED). https://www.allergy.org.au/hp/ascia-plans-action-and-treatment. Accessed December 2021.
  6. Medical Director. Active Ingredient Prescribing is coming: here’s what you need to know. https://www.medicaldirector.com/news/clinical-practice/2020/08/active-ingredient-prescribing-is-coming-heres-what-you-need-to-know. Accessed December 2021.

February 2022. EPI-2021-0567.